I am a researcher interested in using quantitative MRI, particularly (but not limited to) diffusion-weighted MRI, for the study of neurological disorders, with special interest in epilepsy. Along with the great people in the lab, we try to understand what causes some specific brain lesions to be epileptogenic, how this process evolves over time, and how it affects cognitive abilities. Some of these questions can be addressed in clinical research, but when it is not possible, we turn to animal models, where we have more control, and are able to use other methods on top of MRI. I joined the National Autonomous University of Mexico in 2010, and started the Brain Connectivity Laboratory in 2012. The type of work that I most enjoy is multidisciplinary by nature, and I have the fortune of having great collaborators.
Since 2014, I have led the National Laboratory for magnetic resonance imaging, which serves several research groups from all over Mexico. This has fortunately forced me to keep up with different quantitative MRI methods.
Interests
- Epilepsy
- Diffusion-weighted magnetic resonance imaging (dMRI)
- Quantitative MRI
Education
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Postdoc in imaging of epilepsy, 2008-2010
Montreal Neurological Hospital
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PhD in Biomedical Engineering / Medical Science, 2003-2007
University of Alberta
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Medical School, 1995-2002
Universidad Autónoma de San Luis Potosí, Mexico
Latest
- Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy
- White matter structural bases for phase accuracy during tapping synchronization
- Light-Weight Neural Network for Intra-voxel Structure Analysis
- Validation of Tenths Stereotactic Coordinates Method Using Probabilistic Tractography of the Ansa Lenticularis in Parkinson’s disease Patients
- Repeat It without Me: Crowdsourcing the T1 Mapping Common Ground via the ISMRM Reproducibility Challenge
- Atypical connectome topography and signal flow in temporal lobe epilepsy
- Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI
- Selective Medial Septum Lesions in Healthy Rats Induce Longitudinal Changes in Microstructure of Limbic Regions, Behavioral Alterations, and Increased Susceptibility to Status Epilepticus
- ILAE neuroimaging task force highlight: Subcortical laminar heterotopia
- Pre-supplementary Motor Cortex Mediates Learning Transfer from Perceptual to Motor Timing
- The neurovascular unit of capillary blood vessels in the rat nervous system. A rapid-Golgi electron microscopy study
- Results of the ISMRM 2020 joint Reproducible Research & Quantitative MR study groups reproducibility challenge on phantom and human brain T1 mapping
- Simultaneous and independent electroencephalography and magnetic resonance imaging: A multimodal neuroimaging dataset
- Altered functional connectivity and network excitability in a model of cortical dysplasia
- Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection
- Altered functional connectivity and network excitability in a model of cortical dysplasia
- Differentiation of white matter histopathology using b-tensor encoding and machine learning
- Tractography passes the test: results from the diffusion-simulated connectivity (DiSCo) challenge
- Neurocysticercosis and Epilepsy: Imaging and Clinical Characteristics
- Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection
- Multi-tensor diffusion abnormalities of gray matter in an animal model of cortical dysplasia
- Atypical intrinsic neural timescales in temporal lobe epilepsy
- Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei
- Prenatal cafeteria diet primes anxiety-like behavior associated to defects in volume and diffusion in the fimbria-fornix of mice offspring
- Preservation of EEG spectral power features during simultaneous EEG-fMRI
- Micapipe: A pipeline for multimodal neuroimaging and connectome analysis
- Brain circuits activated by female sexual behavior evaluated by manganese enhanced magnetic resonance imaging
- Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
- Event-based modelling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data
- Superficial and deep white matter diffusion abnormalities in focal epilepsies
- Imaging Characteristics of Temporopolar Blurring in the Context of Hippocampal Sclerosis
- Life-Long Arsenic Exposure Damages the Microstructure of the Rat Hippocampus
- Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy
- Improved Post-Stroke Spontaneous Recovery by Astrocytic Extracellular Vesicles
- A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies
- Tractography Dissection Variability: What Happens When 42 Groups Dissect 14 White Matter Bundles on the Same Dataset?
- Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study
- MRI-and histologically derived neuroanatomical atlas of the Ambystoma mexicanum (axolotl)
- Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state
- Chronobiotic effect of melatonin in experimental optic neuritis
- Longitudinal changes in gray and white matter microstructure during epileptogenesis in pilocarpine-induced epileptic rats
- PREEMACS: Pipeline for Preprocessing and Extraction of the Macaque Brain Surface
- Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study
- Propylparaben Reduces the Long-Term Consequences in Hippocampus Induced by Traumatic Brain Injury in Rats: Its Implications as Therapeutic Strategy to Prevent Neurodegenerative Diseases
- White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study
- Long-Term Improvement of Parkinson Disease Motor Symptoms Derived From Lesions of Prelemniscal Fiber Tract Components
- Memory deficits in Sprague Dawley rats with spontaneous ventriculomegaly
- Sodium cromoglycate decreases sensorimotor impairment and hippocampal alterations induced by severe traumatic brain injury in rats
- The ENIGMA-Epilepsy working group: Mapping disease from large data sets
- Demyelination associated with chronic arsenic exposure in Wistar rats
- Maximum smoothness consistent unwrapping of n-dimensional phase fields
- Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy
- Demyelination–Remyelination of the Rat Caudal Cerebellar Peduncle Evaluated with Magnetic Resonance Imaging
- Discerning the functional networks behind processing of music and speech through human vocalizations
- Histological and diffusion-weighted magnetic resonance imaging data from normal and degenerated optic nerve and chiasm of the rat
- Histological validation of per-bundle water diffusion metrics within a region of fiber crossing following axonal degeneration
- On the existence of mechanoreceptors within the neurovascular unit of the mammalian brain
- TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice
- Association of white matter diffusion characteristics and cognitive deficits in temporal lobe epilepsy
- Histological and MRI markers of white matter damage in focal epilepsy
- Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
- Anatomic characterization of prelemniscal radiations by probabilistic tractography: implications in Parkinson’s disease
- Tactile object categories can be decoded from the parietal and lateral-occipital cortices
- The rat corticospinal system is functionally and anatomically segregated
- Our faces in the dog's brain: Functional imaging reveals temporal cortex activation during perception of human faces
- White matter in temporal lobe epilepsy: clinico-pathological correlates of water diffusion abnormalities
- Child overweight and obesity are associated with reduced executive cognitive performance and brain alterations: A magnetic resonance imaging study in Mexican children
- Metabolic Changes Induced by Electrical Stimulation of Prelemniscal Radiations for the Treatment of Parkinson Disease
- The specificity of neural responses to music and their relation to voice processing: An fMRI-adaptation study
- A macroscopic view of microstructure: Using diffusion-weighted images to infer damage, repair, and plasticity of white matter
- Correlation between corpus callosum sub-segmental area and cognitive processes in school-age children
- Correlations between limbic white matter and cognitive function in temporal-lobe epilepsy, preliminary findings
- Music listening engages specific cortical regions within the temporal lobes: Differences between musicians and non-musicians
- Music perception: Information flow within the human auditory cortices
- Sustained attention to spontaneous thumb sensations activates brain somatosensory and other proprioceptive areas
- The parietal cortices participate in encoding, Short-term memory, and decision-making related to tactile shape
- Diffusion Weighted Image Denoising Using Overcomplete Local PCA
- Fear across the senses: Brain responses to music, vocalizations and facial expressions
- The acute phase of Wallerian degeneration: Longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery
- Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy
- Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy
- Comment
- Distinct white matter abnormalities in different idiopathic generalized epilepsy syndromes
- Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis
- Corpus callosum and cingulum tractography in Parkinson's disease
- Cortical thickness analysis in temporal lobe epilepsy: Reproducibility and relation to outcome
- In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy
- Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography
- White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis
- Diffusion tensor imaging tractography and reliability analysis for limbic and paralimbic white matter tracts
- Insights into the sequence of structural consequences of convulsive status epilepticus: A longitudinal MRI study
- Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: Insights on the relation between mesiotemporal connectivity and cortical atrophy
- Motor cortex and spinal degeneration in multisystem atrophy: A multimodal study
- Thalamic diffusion and volumetry in temporal lobe epilepsy with and without mesial temporal sclerosis
- Bilateral white matter diffusion changes persist after epilepsy surgery
- Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging
- Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients
- Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging
- Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy
- Diffusion tensor tractography of the limbic system
- Imaging brain connectivity in children with diverse reading ability